Description

6-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid is a high-value trifluoromethylated pyrimidine derivative, a key building block in modern synthetic chemistry. Its core value lies in the trifluoromethyl group, which is strategically incorporated into molecules to enhance their metabolic stability, lipophilicity, and binding affinity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced materials with unique electronic or surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, amide bond formations, and other transformations to construct complex, fluorinated heterocyclic scaffolds.
• Chemical Biology & Medicinal Chemistry: Utilized in the design and synthesis of chemical probes and tool compounds for target validation and biochemical pathway studies.

Basic Information

Product Name	6-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid
CAS No.	933721-99-4
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	4-Pyrimidinecarboxylic acid, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)pyrimidine-4-carboxylic acid; 6-Trifluoromethyl-4-pyrimidinecarboxylic acid; 6-Trifluoromethylpyrimidine-4-carboxylic acid; 933721-99-4; 4-Carboxy-6-trifluoromethylpyrimidine
EINECS	Contact for details

Quality Control

Our 6-Trifluoromethyl-Pyrimidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.