Description

4-Chloropyrimidine-5-Carbaldehyde is a versatile and high-value heterocyclic building block, essential for constructing complex molecular architectures. Its core value lies in the strategic reactivity of both the chloropyrimidine ring and the aldehyde functional group, enabling precise synthetic modifications. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Material Science Research: Employed in the synthesis of organic semiconductors, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Cross-Coupling Reactions: The chlorine substituent makes it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Nucleoside & Nucleotide Chemistry: Acts as a building block for modified nucleosides and related bioactive compounds.

Basic Information

Product Name	4-Chloropyrimidine-5-Carbaldehyde
CAS No.	933703-03-8
Molecular Formula	C5H3ClN2O
Molecular Weight	142.54 g/mol
Synonyms	5-Formyl-4-chloropyrimidine; 4-Chloro-5-pyrimidinecarboxaldehyde; 4-Chloro-5-formylpyrimidine; 4-Chloropyrimidine-5-carboxaldehyde; 5-Pyrimidinecarboxaldehyde, 4-chloro-; 4-Chloro-5-pyrimidinecarbaldehyde; 4-Chloro-5-pyrimidinealdehyde; 933703-03-8
EINECS	Contact for details

Quality Control

Our 4-Chloropyrimidine-5-Carbaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.