Description

2-Chloropyrimidine-5-Carbaldehyde is a versatile and high-value heterocyclic building block, primarily used in advanced organic synthesis. Its core value lies in the reactive aldehyde and chloropyrimidine functionalities, which enable efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, serving as a key intermediate for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Synthesis: Used to construct novel pyrimidine-based herbicides, fungicides, and plant growth regulators.
• Material Science Building Block: Employed in the development of organic ligands for catalysis, metal-organic frameworks (MOFs), and functional polymers.
• Cross-Coupling Reactions: The chlorine atom facilitates palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for carbon-carbon and carbon-heteroatom bond formation.
• Nucleophilic Substitution: The aldehyde group allows for condensation reactions (e.g., with amines to form imines) and further functionalization.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry and process chemistry for exploring new chemical spaces.

Basic Information

Product Name	2-Chloropyrimidine-5-Carbaldehyde
CAS No.	933702-55-7
Molecular Formula	C5H3ClN2O
Molecular Weight	142.54 g/mol
Synonyms	5-Formyl-2-chloropyrimidine; 2-Chloro-5-pyrimidinecarboxaldehyde; 2-Chloropyrimidine-5-carboxaldehyde; 2-Chloro-5-formylpyrimidine; Pyrimidine-5-carboxaldehyde, 2-chloro-; 5-Carbaldehyde-2-chloropyrimidine; 2-Chloro-5-pyrimidinecarbaldehyde
EINECS	Contact for details

Quality Control

Our 2-Chloropyrimidine-5-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.