Description

Propargyl-Peg3-Nh2 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and a primary amine group for conjugation to carboxylates or other electrophilic sites. This compound is essential for creating stable, well-defined bioconjugates and functionalized materials with precise control over architecture and spacing. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a critical linker to attach cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via its amine and alkyne functionalities.
• PEGylation and Drug Delivery Systems: Serves as a heterobifunctional PEG spacer to modify therapeutic proteins, peptides, or nanoparticles, improving solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization and Material Science: Enables the covalent attachment of biomolecules or functional groups to surfaces, hydrogels, or polymers for biosensor, diagnostic assay, and biomaterial applications.
• Click Chemistry Scaffolding: Acts as a versatile building block in the synthesis of complex molecular architectures, dendrimers, and polymer networks through efficient CuAAC reactions.
• Probe and Diagnostic Reagent Synthesis: Facilitates the creation of labeled probes for imaging, detection, and diagnostic purposes by linking targeting molecules to reporter groups.
• Crosslinking Agent: Employed to crosslink polymers or biomolecules, forming stable networks for tissue engineering scaffolds or controlled release matrices.

Basic Information

Product Name	Propargyl-Peg3-Nh2
CAS No.	932741-19-0
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	1-Amino-3,6,9-trioxa-12-dodecyne; 2,5,8,11-Tetraoxatetradec-13-yn-14-amine; Propargyl-PEG3-amine; Propargyl-PEG3-NH2; N-(Prop-2-yn-1-yl)-3,6,9-trioxaundecane-1,11-diamine (common representation); Alkyne-PEG3-amine; 13-Amino-4,7,10-trioxatridec-1-yne; Propargyl-O3-amine
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.