Description

cis-4-Fluoro-Cyclohexylamine Hydrochloride is a high-purity, fluorinated chiral amine salt with significant utility in advanced organic synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where the introduction of a fluorine atom and a specific stereochemistry is critical for modulating biological activity and physicochemical properties. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecular entities.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, particularly in CNS and metabolic disease therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine moiety enhances stability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptide Mimetics & Modifications: Incorporated into peptide chains to improve metabolic stability and membrane permeability.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with unique properties.
• Chemical Biology Probes: Used to create labeled compounds and probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	cis-4-Fluoro-Cyclohexylamine Hydrochloride
CAS No.	932706-30-4
Molecular Formula	C6H13ClFN
Molecular Weight	153.63 g/mol
Synonyms	cis-4-Fluorocyclohexanamine hydrochloride; (1r,4r)-4-Fluorocyclohexan-1-amine hydrochloride; 4-Fluorocyclohexylamine hydrochloride (cis-); 4-Fluoro-cyclohexylamine HCl (cis-); trans-4-Fluorocyclohexylamine hydrochloride (isomer); 4-FCA HCl; 4-Fluorocyclohexanamine HCl
EINECS	Contact for details

Quality Control

Our cis-4-Fluoro-Cyclohexylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (cis-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.