Description

Troplasminogen Alfa CAS NO 931101-84-7 is a high-purity, recombinant protein designed for advanced therapeutic and research applications. This compound is critical for its role in targeted thrombolytic therapy, offering a precise mechanism of action for clot dissolution. It is primarily utilized by pharmaceutical manufacturers and biotechnology research institutions engaged in the development of next-generation cardiovascular and hematological treatments.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of thrombolytic drugs for treating acute ischemic stroke and myocardial infarction.
• Biomedical Research: Used as a key reagent in studies of the fibrinolytic system, plasminogen activation pathways, and thrombosis models.
• Preclinical & Clinical Development: Essential for efficacy and safety testing in drug development pipelines for cardiovascular diseases.
• Reference Standard: Serves as a high-purity standard for quality control and assay calibration in analytical laboratories.
• Bioconjugation & Drug Delivery Systems: A candidate for engineered fusion proteins or targeted drug delivery platforms due to its specific activity.

Basic Information

Product Name	Troplasminogen Alfa
CAS No.	931101-84-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Recombinant Troplasminogen Alfa; Plasminogen Activator Variant; r-Troplasminogen; Thrombolytic Protein; Fibrinolytic Enzyme; Therapeutic Plasminogen; Alteplase variant; rPA (recombinant Plasminogen Activator)
EINECS	Contact for details

Quality Control

Our Troplasminogen Alfa is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, aligning with ICH Q6B guidelines for biotechnological products. Certificates of Analysis (COA) documenting purity by HPLC, biological activity, endotoxin levels, and sterility are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize condensation. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/Peptide Map)	Conforms to reference standard
Purity (SDS-PAGE, reduced)	≥ 95.0 %
Purity (SEC-HPLC)	≥ 98.0 %
Biological Activity (Clot Lysis Assay)	≥ 90.0 % of stated potency
Endotoxin	< 1.0 EU/mg
Residual Moisture (KF)	< 3.0 %
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.