Description

2,4-Dichloroquinazoline-6-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride and halogenated quinazoline moieties. This compound is essential for the synthesis of complex molecules, enabling the introduction of the quinazoline pharmacophore and facilitating further derivatization via nucleophilic substitution. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients, including kinase inhibitors and herbicides.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of targeted therapeutics, particularly protein kinase inhibitors and other small-molecule drugs.
• Agrochemical Research: Used in creating novel herbicide and pesticide candidates by exploiting its bioactive quinazoline core.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization to create sulfonamides, amines, and other derivatives.
• Material Science: Potential intermediate in the development of advanced organic materials and functional dyes.
• Bioconjugation & Probe Development: The reactive sulfonyl chloride group allows for labeling and modifying biomolecules in research settings.

Basic Information

Product Name	2,4-Dichloroquinazoline-6-Sulfonyl Chloride
CAS No.	930396-18-2
Molecular Formula	C8H3Cl3N2O2S
Molecular Weight	321.54 g/mol
Synonyms	6-(Chlorosulfonyl)-2,4-dichloroquinazoline; 2,4-Dichloro-6-quinazolinesulfonyl chloride; Quinazoline-6-sulfonyl chloride, 2,4-dichloro-; 930396-18-2; 2,4-Dichloroquinazoline-6-sulfonylchloride
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloroquinazoline-6-Sulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and synthesis. A detailed Certificate of Analysis (COA), including results for purity (HPLC), identity (IR, NMR), and impurity profiles, is supplied with each shipment and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.