Description

(S)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanamine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical synthesis. Its value lies in providing a structurally defined, fluorinated pharmacophore critical for modulating the potency, metabolic stability, and bioavailability of target drug molecules. This compound is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in CNS and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting neurological disorders.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the trifluoromethyl and fluorophenyl groups enhance biological activity and environmental stability.
• Asymmetric Catalysis: Serves as a chiral ligand precursor or auxiliary in stereoselective synthesis to create enantiomerically pure compounds.
• Fluorine Chemistry Studies: A valuable reference compound for investigating the effects of fluorine substitution on molecular properties and reactivity.
• Peptidomimetics & Bioisosteres: Incorporated into peptide analogs where the trifluoroethylamine moiety acts as a bioisostere for natural amino acids to improve drug-like properties.
• Material Science Precursor: Potential use in synthesizing specialty polymers and liquid crystals that require fluorinated aromatic amines.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanamine Hydrochloride
CAS No.	929642-58-0
Molecular Formula	C8H8ClF4N
Molecular Weight	229.60 g/mol
Synonyms	(S)-1-(4-Fluorophenyl)-2,2,2-trifluoroethanamine hydrochloride; (S)-α-(4-Fluorophenyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-4-Fluoro-α-(trifluoromethyl)benzylamine hydrochloride; (S)-2,2,2-Trifluoro-1-(4-fluorophenyl)ethylamine HCl; (S)-1-(4-Fluorophenyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-F-PEA-TFA HCl; (S)-4-Fluoro-α-(trifluoromethyl)benzenemethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.