Description

n-(5-Amino-2-Fluorophenyl)Isonicotinamide is a high-purity, fluorinated aromatic amide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical candidates and agrochemicals, where its unique fluorine-substituted aniline core imparts desirable biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and receptor modulator research.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorinated aniline moiety.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Can be utilized in the synthesis of specialty polymers or ligands for catalytic systems.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and novel compound library synthesis.

Basic Information

Product Name	n-(5-Amino-2-Fluorophenyl)Isonicotinamide
CAS No.	926227-20-5
Molecular Formula	C12H10FN3O
Molecular Weight	231.23 g/mol
Synonyms	5-Amino-2-fluoro-N-(pyridin-4-yl)benzamide; 4-Pyridinecarboxamide, N-(5-amino-2-fluorophenyl)-; N-(5-Amino-2-fluorophenyl)pyridine-4-carboxamide; 926227-20-5; Isonicotinamide, N-(5-amino-2-fluorophenyl)-; AKOS005258991; FT-0697926; N-(5-Amino-2-fluorophenyl)isonicotinamide
EINECS	Contact for details

Quality Control

Our n-(5-Amino-2-Fluorophenyl)Isonicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature and potential for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.