Description

Fmoc-5-Bromo-Dl-Tryptophan is a protected, halogenated derivative of the essential amino acid tryptophan, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of modified tryptophan residues into complex peptide sequences, enabling advanced research in medicinal chemistry and drug discovery. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise construction of custom peptides, particularly those requiring brominated tryptophan analogs.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide libraries for structure-activity relationship (SAR) studies, high-throughput screening, and the development of novel bioactive compounds targeting GPCRs, enzymes, and other protein targets.
• Bioconjugation & Probe Development: The bromine atom serves as a versatile handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling the attachment of fluorophores, biotin, or other tags for creating diagnostic or imaging probes.
• Academic & Industrial Research: Essential for fundamental studies in peptide science, protein-protein interactions, and the exploration of post-translational modifications in a controlled laboratory setting.
• Production of Non-Natural Peptides: Facilitates the incorporation of a heavy atom (bromine) into peptide backbones for X-ray crystallography studies or to modulate peptide stability, lipophilicity, and receptor binding affinity.

Basic Information

Product Name	Fmoc-5-Bromo-Dl-Tryptophan
CAS No.	925939-82-8
Molecular Formula	C₂₆H₂₁BrN₂O₄
Molecular Weight	505.36 g/mol
Synonyms	Fmoc-5-Bromo-DL-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-bromo-DL-tryptophan; 5-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-DL-tryptophan; Fmoc-5-Br-DL-Trp; Fmoc-5-Bromo-DL-Tryptophane; 5-Bromo-DL-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromo-1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-5-Bromo-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for advanced peptide synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.