Description

2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3,3-Difluoropropanoic Acid is a specialized Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise introduction of a difluoromethyl group, a key bioisostere that can dramatically improve the metabolic stability and binding affinity of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in peptide synthesis and the development of novel therapeutics, including protease inhibitors and other bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, sequential construction of complex peptides and peptidomimetics.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those targeting enzymes where the difluoromethyl moiety enhances drug-like properties.
• Protease Inhibitor Development: The 3,3-difluoropropanoic acid scaffold is valuable for creating inhibitors of various proteases, a major class of drug targets.
• Chemical Biology & Probe Synthesis: Employed to synthesize labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Bioconjugation: Can be used to introduce fluorinated linkers or handles into biomolecules for further functionalization or analytical purposes.
• Material Science Research: Potential use in creating novel fluorinated polymers or surfaces with unique properties derived from peptide-based structures.

Basic Information

Item	Details
Product Name	2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3,3-Difluoropropanoic Acid
CAS No.	925422-84-0
Molecular Formula	C18H15F2NO4
Molecular Weight	347.31 g/mol
Synonyms	Fmoc-3,3-difluoroalanine; Fmoc-Difluoroalanine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-difluoroalanine; 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3,3-difluoropropanoic acid; Fmoc-3,3-F2-Ala-OH; (2R/S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,3-difluoropropanoic acid (racemic); N-α-Fmoc-3,3-difluoro-L-alanine
EINECS	Contact for details

Quality Control

Our 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3,3-Difluoropropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.