Description

[4-[[5-Fluoro-4-[2-Methyl-1-(1-Methylethyl)-1H-Imidazol-5-Yl]-2-Pyrimidinyl]Amino]Phenyl][(3S)-3-(Methylamino)-1-Pyrrolidinyl]Methanone is a high-purity, non-racemic chiral compound featuring a complex heterocyclic structure. This advanced pharmaceutical intermediate is critical for the research and development of targeted therapeutic agents, particularly in oncology. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of investigational small-molecule drugs, especially kinase inhibitors.
• Oncology Research: Used in the development of targeted cancer therapies due to its specific molecular scaffold.
• Chemical Biology: Serves as a probe or tool compound for studying specific biological pathways and protein interactions.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Reference Standard: Provides a certified standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for client-specific research programs.

Basic Information

Product Name	[4-[[5-Fluoro-4-[2-Methyl-1-(1-Methylethyl)-1H-Imidazol-5-Yl]-2-Pyrimidinyl]Amino]Phenyl][(3S)-3-(Methylamino)-1-Pyrrolidinyl]Methanone
CAS No.	924641-59-8
Molecular Formula	C24H28FN7O
Molecular Weight	449.52 g/mol
Synonyms	(3S)-N-Methyl-1-[[4-[[5-fluoro-4-[2-methyl-1-(propan-2-yl)imidazol-5-yl]pyrimidin-2-yl]amino]phenyl]carbonyl]pyrrolidin-3-amine; (S)-N-Methyl-1-(4-((5-fluoro-4-(2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl)pyrimidin-2-yl)amino)benzoyl)pyrrolidin-3-amine; 924641-59-8; UNII-9V7J1K1Q0W; 9V7J1K1Q0W; CHEMBL3186665; BDBM50389373; AKOS025147310.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of [4-[[5-Fluoro-4-[2-Methyl-1-(1-Methylethyl)-1H-Imidazol-5-Yl]-2-Pyrimidinyl]Amino]Phenyl][(3S)-3-(Methylamino)-1-Pyrrolidinyl]Methanone is characterized and released with a comprehensive Certificate of Analysis (COA). We adhere to strict in-process controls and final release specifications, including chiral purity verification, to meet the exacting requirements of pharmaceutical development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.