Description

tert-Butyl 2-Bromo-4-(Trifluoromethyl)Phenylcarbamate is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its unique trifluoromethyl and bromo substituents, which are critical for modulating the biological activity, lipophilicity, and metabolic stability of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers and polymers with unique electronic or surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function and protein interactions within biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	tert-Butyl 2-Bromo-4-(Trifluoromethyl)Phenylcarbamate
CAS No.	924627-62-3
Molecular Formula	C12H13BrF3NO2
Molecular Weight	340.14 g/mol
Synonyms	2-Bromo-4-(trifluoromethyl)phenyl carbamic acid tert-butyl ester; tert-Butyl N-[2-bromo-4-(trifluoromethyl)phenyl]carbamate; BOC-2-Bromo-4-(trifluoromethyl)aniline; 1-(tert-Butoxycarbonylamino)-2-bromo-4-(trifluoromethyl)benzene; N-Boc-2-bromo-4-trifluoromethylaniline; tert-Butyl (2-bromo-4-(trifluoromethyl)phenyl)carbamate; Carbamic acid, N-[2-bromo-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Bromo-4-(Trifluoromethyl)Phenylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory and manufacturing practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.