Description

5-Methoxy-2-Perfluoropropylindole is a specialized fluorinated indole derivative, a high-value building block in advanced organic synthesis. Its core value lies in the unique combination of the indole scaffold and a perfluorinated alkyl chain, which imparts distinct electronic and hydrophobic properties critical for modulating the activity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing novel active ingredients and functional materials where fluorine substitution is a key design strategy.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research where fluorinated indoles are explored for their bioactivity and metabolic stability.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the fluorine atoms to enhance lipophilicity, membrane permeability, and environmental persistence of active compounds.
• Material Science: Acts as a monomer or functional additive in the creation of specialty polymers and coatings, where the perfluoropropyl group contributes to oil/water repellency, chemical resistance, and low surface energy.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, with the electron-withdrawing fluorinated side-chain fine-tuning metal center reactivity.
• Fluorescent Probe Synthesis: Utilized as a core structure for developing advanced fluorescent dyes and molecular probes used in biochemical assays and diagnostic imaging.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling reactions and heterocyclic chemistry involving fluorinated building blocks.

Basic Information

Product Name	5-Methoxy-2-Perfluoropropylindole
CAS No.	923569-79-3
Molecular Formula	C12H8F7NO
Molecular Weight	315.19 g/mol
Synonyms	2-(Perfluoropropyl)-5-methoxyindole; 5-Methoxy-2-(perfluoropropyl)-1H-indole; 5-Methoxy-2-(heptafluoropropyl)indole; 5-Methoxy-2-(1,1,2,2,3,3,3-heptafluoropropyl)-1H-indole; 1H-Indole, 5-methoxy-2-(perfluoropropyl)-; 923569-79-3; 5-Methoxy-2-(heptafluoropropyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 5-Methoxy-2-Perfluoropropylindole is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure consistency and meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.