Description

4,5,6,7-Tetrafluoroindoline is a fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the tetrafluoro substitution, which makes it a critical precursor for developing novel pharmaceuticals and functional materials. This compound is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated indoline scaffolds into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in creating advanced, bioactive molecules for crop protection agents with enhanced stability and efficacy.
• Material Science Precursor: Serves as a building block for fluorinated organic electronic materials, such as those used in OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An essential compound for academic and industrial research exploring the effects of perfluoroarene substitution on heterocyclic systems.
• Custom Synthesis and Scale-up: Supplied for contract research organizations (CROs) and CDMOs requiring high-purity fluorinated intermediates for client projects.

Basic Information

Product Name	4,5,6,7-Tetrafluoroindoline
CAS No.	19282-55-4
Molecular Formula	C8H5F4N
Molecular Weight	191.13 g/mol
Synonyms	2,3-Dihydro-4,5,6,7-tetrafluoro-1H-indole; 4,5,6,7-Tetrafluoro-2,3-dihydroindole; 1H-Indole, 2,3-dihydro-4,5,6,7-tetrafluoro-; Tetrafluoroindoline; 4,5,6,7-Tetrafluorodihydroindole; 4,5,6,7-Tetrafluoro-2,3-dihydro-1H-indole; Perfluoroindoline (informal)
EINECS	Contact for details

Quality Control

Our 4,5,6,7-Tetrafluoroindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.