Description

4,5,6,7-Tetrafluoroindole is a highly fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the tetrafluoro substitution, which makes it a critical precursor for developing novel pharmaceuticals and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating complex, fluorinated target molecules with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas, where fluorine incorporation can improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging fluorine atoms to enhance efficacy and environmental profile.
• Material Science Research: Acts as a monomer or building block for creating novel fluorinated polymers, liquid crystals, or organic electronic materials with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological systems and mechanisms of action.
• Catalyst Ligand Development: Provides a framework for synthesizing specialized fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	4,5,6,7-Tetrafluoroindole
CAS No.	16264-67-8
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2,3,4,5-Tetrafluoro-1H-indole; 1H-Indole, 2,3,4,5-tetrafluoro-; Tetrafluoroindole; 4,5,6,7-Tetrafluoro-1H-indole; Indole, 2,3,4,5-tetrafluoro-; 2,3,4,5-Tetrafluoroindole; F4-Indole
EINECS	Contact for details

Quality Control

Our 4,5,6,7-Tetrafluoroindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.