Description

6-(Trifluoromethyl)Indole is a versatile fluorinated heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in the unique electronic and steric properties imparted by the trifluoromethyl group, which is crucial for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3 group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized polymers, organic semiconductors, and liquid crystals.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and enzyme inhibitors.
• Organic Synthesis: A valuable reagent for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other C-H functionalization protocols.
• Fluorine Chemistry Studies: Used in academic and industrial R&D to study the effects of fluorine substitution on indole chemistry and reactivity.

Basic Information

Product Name	6-(Trifluoromethyl)Indole
CAS No.	13544-43-9
Molecular Formula	C9H6F3N
Molecular Weight	185.15 g/mol
Synonyms	6-(Trifluoromethyl)-1H-indole; 1H-Indole, 6-(trifluoromethyl)-; 6-Trifluoromethylindole; 6-CF3-Indole; 6-(Trifluoromethyl)indole; Indole, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-1H-indole; α,α,α-Trifluoro-m-toluidine (related)
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.