Description

4-[(2,2,2-Trifluoroethoxy)Methyl]Aniline is a specialized aromatic amine building block featuring a trifluoroethoxymethyl substituent, offering unique electronic and steric properties for advanced molecular design. This compound is valued for its role in synthesizing high-performance materials and active pharmaceutical ingredients where fluorine incorporation is critical for modulating bioavailability, stability, and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoroethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty polymers with improved chemical resistance and thermal stability.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex, high-value dyes and pigments.
• Chemical Research & Development: A versatile building block for medicinal chemistry, process chemistry, and material science research projects.

Basic Information

Product Name	4-[(2,2,2-Trifluoroethoxy)Methyl]Aniline
CAS No.	923255-94-1
Molecular Formula	C10H12F3NO
Molecular Weight	219.20 g/mol
Synonyms	4-[(2,2,2-Trifluoroethoxy)methyl]benzenamine; 1-Amino-4-[(2,2,2-trifluoroethoxy)methyl]benzene; p-[(2,2,2-Trifluoroethoxy)methyl]aniline; 4-(Trifluoroethoxymethyl)aniline; Benzenamine, 4-[(2,2,2-trifluoroethoxy)methyl]-; 923255-94-1; 4-Aminobenzyl 2,2,2-trifluoroethyl ether
EINECS	Contact for details

Quality Control

Our 4-[(2,2,2-Trifluoroethoxy)Methyl]Aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.