Description

1-Methylcyclopropane-1-Sulfonyl Chloride is a specialized organosulfur reagent primarily used as a versatile sulfonylation and sulfamoylation agent in advanced organic synthesis. Its unique cyclopropane ring structure imparts distinct steric and electronic properties, making it valuable for constructing complex molecular architectures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide and sulfonate-based drug candidates, including protease inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides that require the cyclopropane-sulfonyl moiety for biological activity.
• Material Science: Serves as a precursor for functional polymers and advanced materials with specific surface properties or reactivity.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling, cross-linking, or modifying biomolecules in research applications.
• Custom Synthesis & Process R&D: A critical reagent for contract research organizations (CROs) and development laboratories exploring new synthetic pathways.

Basic Information

Product Name	1-Methylcyclopropane-1-Sulfonyl Chloride
CAS No.	923032-55-7
Molecular Formula	C4H7ClO2S
Molecular Weight	154.61 g/mol
Synonyms	1-Methylcyclopropanesulfonyl chloride; (1-Methylcyclopropyl)sulfonyl chloride; 1-Methyl-1-sulfonylchloridocyclopropane; Cyclopropane, 1-methyl-1-(chlorosulfonyl)-; 1-Methylcyclopropylsulfonyl chloride; 1-MCP-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Methylcyclopropane-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, water content, and related substances. Our quality commitment supports applications requiring material consistency under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a recommended temperature of 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.