Description

Fmoc-D-Cyclopropylglycine is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical chiral building block, valued for introducing the constrained cyclopropyl side chain of D-configuration under Fmoc-protection strategies, which is essential for modulating peptide conformation and biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the incorporation of the rigid D-cyclopropylglycine residue into peptide chains.
• Peptidomimetic Drug Discovery: Used to create conformationally restricted peptide analogs to enhance metabolic stability, receptor selectivity, and bioavailability in candidate drug molecules.
• Structure-Activity Relationship (SAR) Studies: Employed to systematically explore the impact of the cyclopropyl constraint and D-stereochemistry on peptide function and interaction with biological targets.
• Chemical Biology & Probe Development: Serves as a specialized component in the synthesis of labeled or modified peptides used as tools for studying enzymatic mechanisms or protein-protein interactions.
• API Intermediate Synthesis: Acts as a chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) that contain non-standard amino acid motifs.

Basic Information

Product Name	Fmoc-D-Cyclopropylglycine
CAS No.	923012-40-2
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-D-Cpg-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclopropylacetic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-cyclopropylglycine; Fmoc-D-2-Amino-2-cyclopropylacetate; N-Fmoc-D-cyclopropylglycine; D-Cyclopropylglycine Fmoc derivative; Fmoc-D-Cyclopropyl-Gly-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Cyclopropylglycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.