Description

Fmoc-Asn(Trt)-Ser(Psime,Mepro)-Oh CAS NO 920519-33-1 is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling the complex, multi-step assembly of challenging peptide sequences, particularly those containing serine and asparagine residues, by providing selective deprotection pathways. Pharmaceutical researchers and biotechnology companies developing therapeutic peptides, peptidomimetics, and peptide-based diagnostics are the primary users who need this high-purity reagent to ensure synthesis success and final product integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of complex peptide chains on resin.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Synthesis: Serves as a precursor for creating modified peptide analogs with enhanced stability and bioavailability.
• Bioconjugation and Labeling: The orthogonal protecting groups allow for selective modification at specific sites within a peptide sequence.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Research: Essential reagent for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Fmoc-Asn(Trt)-Ser(Psime,Mepro)-Oh
CAS No.	920519-33-1
Molecular Formula	C48H49N5O8
Molecular Weight	823.94 g/mol
Synonyms	Fmoc-Asn(Trt)-Ser(ψMe,Mepro)-OH; Fmoc-N-α-(9-fluorenylmethoxycarbonyl)-N-γ-trityl-L-asparaginyl-O-(1-methyl-1-propenyl)-L-serine; N-α-Fmoc-N-γ-trityl-L-asparaginyl-O-(1-methyl-1-propenyl)-L-serine; Fmoc-Asn(Trt)-Ser[ψ(Me,Mepro)]-OH; Fmoc-L-Asn(Trt)-L-Ser(ψMe,Pro)-OH; Protected Fmoc-Asn-Ser dipeptide; Fmoc-Asn(Trt)-Ser(ψMe,Mepro)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Asn(Trt)-Ser(Psime,Mepro)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to meet the exacting standards of pharmaceutical R&D. Certificates of Analysis (COA) with full chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.