Description

Fmoc-Tyr(Tbu)-Thr(Psi-Me,Mepro)-Oh is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and high-fidelity assembly of complex peptides, particularly those containing challenging sequences or requiring specific post-translational modifications. It is an essential raw material for research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated or manual synthesis of complex peptide chains.
• Pharmaceutical R&D: Building block for the discovery and development of new peptide-based drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptidomimetic Design: Used to incorporate non-natural amino acid analogs and pseudoproline dipeptides to enhance peptide stability, solubility, and bioavailability.
• Bioconjugation: Serves as a precursor for creating peptide tags, linkers, or functionalized peptides for conjugation with other molecules (e.g., dyes, polymers, proteins).
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic Research: Fundamental tool for studying protein folding, structure-activity relationships (SAR), and peptide hormone analogs.

Basic Information

Product Name	Fmoc-Tyr(Tbu)-Thr(Psi-Me,Mepro)-Oh
CAS No.	920519-31-9
Molecular Formula	C₃₃H₄₄N₂O₈
Molecular Weight	608.72 g/mol
Synonyms	Fmoc-Tyr(tBu)-Thr(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-tyrosyl-N-[(2S,4S)-1-methyl-4-(2-methylpropyl)-2-pyrrolidinyl]-L-threoninamide; Fmoc-L-Tyrosine(tBu)-L-Threonine[ψ(Me,Mepro)]; Fmoc-Tyr(tBu)-Thr[ψ(Me,Mepro)]-OH; Pseudoproline Dipeptide Fmoc-Tyr(tBu)-Thr(ψMe,Mepro); Fmoc-Tyr(O-tBu)-Thr(ψMe,Mepro)-OH; Protected Dipeptide 920519-31-9
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Tbu)-Thr(Psi-Me,Mepro)-Oh is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive peptide synthesis. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral integrity is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0%
Specific Rotation	-20° to -30° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.