Description

4-Chloro-1-(3,4-Difluorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of targeted kinase inhibitors and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent and selective kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or a core scaffold in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• API Development: Serves as a critical building block in the research and process development of new Active Pharmaceutical Ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Employed in university and institutional labs for exploring new synthetic methodologies and biological pathways.

Basic Information

Product Name	4-Chloro-1-(3,4-Difluorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidine
CAS No.	919735-36-7
Molecular Formula	C11H5ClF2N4
Molecular Weight	266.63 g/mol
Synonyms	4-Chloro-1-(3,4-difluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-1-(3,4-difluorophenyl)-; 919735-36-7; 4-Chloro-1-(3,4-difluorophenyl)pyrazolo[3,4-d]pyrimidine; 4-Chloro-1-(3,4-difluorophenyl)-7H-pyrazolo[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(3,4-Difluorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.