Description

H-Lys(Ivdde)-Oh CAS NO 919281-76-8 is a protected amino acid derivative, specifically a lysine residue modified with an ivDde (1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl) protecting group on its side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the orthogonal protection strategy essential for constructing complex peptides and bioconjugates. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key intermediate for the controlled, sequential assembly of peptide chains, where the ivDde protecting group can be selectively removed under mild conditions without affecting other common protecting groups like Fmoc or Boc.
• Orthogonal Protection Strategies: Enables the synthesis of complex peptides containing multiple lysine residues or requiring selective modification at specific sites.
• Bioconjugation and Labeling: Used to introduce functional handles (e.g., for attaching fluorescent dyes, biotin, or polyethylene glycol (PEG) chains) at precise locations within a peptide sequence after selective deprotection.
• Pharmaceutical Research: A vital raw material in the research and development of peptide-based drugs, including hormones, antimicrobial peptides, and targeted therapeutics.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for drug discovery and screening purposes.
• Material Science: Used in the design and synthesis of peptide-based polymers, hydrogels, and surface coatings with specific biological functions.

Basic Information

Product Name	H-Lys(Ivdde)-Oh
CAS No.	919281-76-8
Molecular Formula	C19H32N2O5
Molecular Weight	368.47 g/mol
Synonyms	Nε-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)-L-lysine; Fmoc-Lys(ivDde)-OH (precursor); Lys(ivDde); 1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine; Nε-ivDde-L-lysine; (S)-2-Amino-6-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino)hexanoic acid; ivDde-Lys-OH; Protected Lysine Derivative
EINECS	Contact for details

Quality Control

Our H-Lys(Ivdde)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment to ensure it meets the stringent requirements of pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.