Description

Benzenamine, 3-(2,2,2-Trifluoro-1-Methoxyethyl)- is a specialized fluorinated aniline derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique trifluoromethoxyethyl side chain imparts distinct electronic and steric properties, making it valuable for modulating the biological activity and physicochemical profile of target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in CNS and antiviral drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the fluorine moiety enhances lipophilicity and membrane permeability.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate for synthesizing fluorinated polymers and liquid crystals with unique optical and electronic properties.
• Chemical Biology Probes: Foundation for creating tagged molecules and probes used in mechanistic studies and diagnostic assays.

Basic Information

Product Name	Benzenamine, 3-(2,2,2-Trifluoro-1-Methoxyethyl)-
CAS No.	919278-50-5
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	3-[(2,2,2-Trifluoro-1-methoxy)ethyl]aniline; 1-(3-Aminophenyl)-2,2,2-trifluoroethyl methyl ether; m-(2,2,2-Trifluoro-1-methoxyethyl)aniline; 3-(2,2,2-Trifluoro-1-methoxyethyl)phenylamine; 3-(α-Methoxy-2,2,2-trifluoroethyl)aniline; (3-Aminophenyl)(2,2,2-trifluoro-1-methoxy)ethane; 919278-50-5 (CAS Name)
EINECS	Contact for details

Quality Control

Our Benzenamine, 3-(2,2,2-Trifluoro-1-Methoxyethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (typical)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.