Description

Methyl 3-(4-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific therapeutic areas. It is essential for research and development organizations, contract manufacturing organizations (CMOs), and pharmaceutical companies engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for drug discovery and development.
• API Synthesis: Used in the multi-step manufacturing process of potential Active Pharmaceutical Ingredients (APIs), especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the creation of focused compound libraries.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service providers supporting pharmaceutical clients with custom synthesis and scale-up projects.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in regulatory submissions.

Basic Information

Product Name	Methyl 3-(4-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate
CAS No.	917889-25-9
Molecular Formula	C16H11FN2O4
Molecular Weight	314.27 g/mol
Synonyms	7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-3-(4-fluorophenyl)-2,4-dioxo-, methyl ester; Methyl 3-(p-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate; 3-(4-Fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylic acid methyl ester; CAS 917889-25-9
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(4-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydroquinazoline-7-Carboxylate adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). Certificates of Analysis (COA) detailing all test results are provided to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.