Description

6-Chloro-9-(2-o-Acetyl-5-o-Benzoyl-3-Azido-3-Deoxy-β-D-Ribofuranosyl)-9H-Purine CAS NO 917239-29-3 is a sophisticated nucleoside analog building block, a key intermediate in advanced pharmaceutical research and development. Its complex structure, featuring a purine base with a modified ribose sugar bearing acetyl, benzoyl, and azido functional groups, makes it a critical precursor for synthesizing novel antiviral and anticancer agents. This high-purity compound is essential for medicinal chemists and research institutions focused on developing next-generation therapeutics, particularly in the fields of nucleoside-based drugs and prodrugs.

Application

• Pharmaceutical Intermediate: A vital building block for the synthesis of novel nucleoside analog drugs targeting viral infections and cancer.
• Antiviral Drug Research: Used in the R&D of prodrugs and active pharmaceutical ingredients (APIs) for hepatitis, HIV, and other viral diseases.
• Anticancer Agent Development: Serves as a key precursor in creating purine-based compounds that interfere with cancer cell DNA/RNA synthesis.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic candidates.
• Bioconjugation & Probe Synthesis: The reactive azido group allows for click chemistry applications, useful in creating labeled probes for biochemical studies.
• Academic & Institutional Research: Employed in university and government labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	6-Chloro-9-(2-o-Acetyl-5-o-Benzoyl-3-Azido-3-Deoxy-β-D-Ribofuranosyl)-9H-Purine
CAS No.	917239-29-3
Molecular Formula	C21H18ClN7O5
Molecular Weight	483.86 g/mol
Synonyms	9-(2-O-Acetyl-5-O-benzoyl-3-azido-3-deoxy-β-D-ribofuranosyl)-6-chloro-9H-purine; 6-Chloropurine-9-(2-acetyl-5-benzoyl-3-azido-3-deoxy-β-D-ribofuranoside); 3'-Azido-2',5'-di-O-acyl-6-chloropurine riboside; 6-Chloro-9H-purine, 9-[2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-β-D-ribofuranosyl]-; AZT/6-Chloropurine Intermediate; 3'-Azido-2',5'-di-O-(acetyl/benzoyl)-6-chloropurine nucleoside
EINECS	Contact for details

Quality Control

Our 6-Chloro-9-(2-o-Acetyl-5-o-Benzoyl-3-Azido-3-Deoxy-β-D-Ribofuranosyl)-9H-Purine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This compound is light-sensitive and should be stored away from light. It is also easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as argon or nitrogen. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.