Description

(R)-Fmoc-4-Amino-5-(3-Indolyl)-Pentanoic Acid CAS NO 917099-01-5 is a high-purity, non-natural amino acid derivative featuring a side-chain indole moiety and an Fmoc-protected amine. This compound is a critical chiral building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of tryptophan-like residues with precise stereochemical control. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, peptide hormones, and constrained macrocycles targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel peptide-based drugs and bioactive compounds.
• Peptide Synthesis: Used in Fmoc-strategy solid-phase peptide synthesis (SPPS) to incorporate a stereochemically defined tryptophan analog into peptide chains.
• Peptidomimetic Design: Serves as a building block for creating conformationally constrained peptidomimetics and macrocyclic peptides with enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides and activity-based probes for studying enzyme mechanisms and protein-protein interactions.
• API Development: Supports the process development and scale-up of Active Pharmaceutical Ingredients (APIs) for clinical and commercial manufacturing.

Basic Information

Product Name	(R)-Fmoc-4-Amino-5-(3-Indolyl)-Pentanoic Acid
CAS No.	917099-01-5
Molecular Formula	C₂₈H₂₆N₂O₄
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-D-4-amino-5-(1H-indol-3-yl)pentanoic acid; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-5-(1H-indol-3-yl)pentanoic acid; Fmoc-D-Bta(4)OH; Fmoc-(R)-4-Amino-5-(3-indolyl)valeric acid; Fmoc-D-4-Amino-5-(indol-3-yl)pentanoic Acid; D-Fmoc-4-Amino-5-(3-Indolyl)pentanoic Acid
EINECS	Contact for details

Quality Control

Our (R)-Fmoc-4-Amino-5-(3-Indolyl)-Pentanoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.