Description

Di-tert-Butyl 5-Methyl-2,4-Dioxopyrimidine-1,3(2H,4H)-Dicarboxylate is a high-purity, protected pyrimidine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer therapies.
• Medicinal Chemistry Research: Used as a protected scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable, GMP-compliant manufacturing of active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and plant growth regulators containing pyrimidine motifs.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and molecular probes for studying biological pathways and enzyme mechanisms.
• Academic & Contract Research: Fundamental reagent for heterocyclic chemistry research and custom synthesis projects in university and CRO laboratories.

Basic Information

Item	Details
Product Name	Di-tert-Butyl 5-Methyl-2,4-Dioxopyrimidine-1,3(2H,4H)-Dicarboxylate
CAS No.	917081-58-4
Molecular Formula	C15H22N2O6
Molecular Weight	326.35 g/mol
Synonyms	1,3-Di-tert-butyl 5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1,3-dicarboxylate; 5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1,3-dicarboxylic Acid Di-tert-butyl Ester; Di-tert-butyl 5-methylbarbiturate-1,3-dicarboxylate; 5-Methylbarbituric Acid Di-tert-butyl Ester; 1,3-Bis(tert-butoxycarbonyl)-5-methylpyrimidine-2,4(1H,3H)-dione; Di-Boc-5-methylbarbituric Acid; 5-Methyl-di-Boc-barbituric Acid
EINECS	Contact for details

Quality Control

Our Di-tert-Butyl 5-Methyl-2,4-Dioxopyrimidine-1,3(2H,4H)-Dicarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.