Description

1H-Pyrazolo[3,4-D]Pyrimidin-4-Ol is a high-purity pharmaceutical intermediate and heterocyclic building block of significant importance in modern medicinal chemistry. This compound serves as a key synthetic precursor for the development of novel therapeutic agents, particularly kinase inhibitors. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted drugs for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of small molecule kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Biochemical Tool Compound: Serves as a core scaffold for developing probes to study enzyme function and cellular signaling pathways.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in universities and research institutes for exploring new chemical entities and their biological activities.

Basic Information

Item	Details
Product Name	1H-Pyrazolo[3,4-D]Pyrimidin-4-Ol
CAS No.	916980-04-6
Molecular Formula	C5H4N4O
Molecular Weight	136.11 g/mol
Synonyms	1H-Pyrazolo[3,4-d]pyrimidin-4-ol; 4-Hydroxy-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one; 4-Hydroxypyrazolo[3,4-d]pyrimidine; 4(1H)-Pyrazolo[3,4-d]pyrimidinone; 4-Pyrazolo[3,4-d]pyrimidinol; 916980-04-6; Pyrazolopyrimidinone derivative
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-D]Pyrimidin-4-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances. Our quality commitment ensures material suitable for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.