Description

1-(4-Chloro-Pyrimidin-2-Yl)-Piperidin-3-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine-pyrimidine core structure. This compound is critical for the synthesis of targeted small molecule drugs, particularly in oncology and other therapeutic areas where precise molecular scaffolds are required. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and active pharmaceutical ingredient (API) manufacturers engaged in novel drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Synthesis: Acts as a versatile precursor for further functionalization to create diverse chemical libraries.
• Active Pharmaceutical Ingredient (API) Development: Incorporated into the final synthetic route for candidate drug molecules under clinical investigation.
• Contract Manufacturing: Supplied to CDMOs for scale-up production under current Good Manufacturing Practice (cGMP) standards.
• Biochemical Research: Potential use as a tool compound or probe in biochemical and pharmacological assays.

Basic Information

Product Name	1-(4-Chloro-Pyrimidin-2-Yl)-Piperidin-3-Ol
CAS No.	916791-09-8
Molecular Formula	C9H10ClN3O
Molecular Weight	211.65 g/mol
Synonyms	3-Piperidinol, 1-(4-chloro-2-pyrimidinyl)-; 1-(4-Chloro-2-pyrimidinyl)-3-piperidinol; 1-(4-Chloropyrimidin-2-yl)piperidin-3-ol; 3-Hydroxy-1-(4-chloro-2-pyrimidinyl)piperidine; Piperidin-3-ol, 1-(4-chloro-2-pyrimidinyl)-; 916791-09-8
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-Pyrimidin-2-Yl)-Piperidin-3-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive analytical data including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, and material can be produced to meet specific customer requirements or in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.