Description

Fmoc-Nh-(Peg)2-Cooh is a specialized polyethylene glycol (PEG)-based linker molecule featuring an Fmoc-protected amine and a terminal carboxylic acid. This bifunctional reagent is critical for constructing complex molecular architectures, particularly in the synthesis of peptide-PEG conjugates and antibody-drug conjugates (ADCs). It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require precise, water-soluble spacers to enhance the pharmacokinetic properties of therapeutic agents.

Application

• Peptide-PEG Conjugate Synthesis: Serves as a key building block for introducing hydrophilic PEG spacers into peptide sequences, improving solubility and bioavailability.
• Antibody-Drug Conjugate (ADC) Development: Used as a heterobifunctional linker to connect cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of dyes, probes, or other molecules to proteins, peptides, or surfaces for diagnostic and research applications.
• Polymer Chemistry: Acts as a functional initiator or monomer in the synthesis of tailored, functionalized PEG-based polymers and hydrogels.
• Drug Delivery Systems: Incorporated into the design of prodrugs and nanocarriers to control drug release kinetics and enhance tissue penetration.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a handle or spacer on resin to facilitate the synthesis of challenging or long peptide sequences.

Basic Information

Product Name	Fmoc-Nh-(Peg)2-Cooh
CAS No.	916585-44-9
Molecular Formula	C27H33NO8
Molecular Weight	499.56 g/mol
Synonyms	Fmoc-NH-PEG2-COOH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,6-dioxaoctanedioic acid; 2-[2-[2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]ethoxy]acetic acid; Fmoc-8-amino-3,6-dioxaoctanoic acid; Fmoc-AEEA-OH; Fmoc-N-amido-PEG2-acid; Fmoc-PEG2-acid; PEG-based Fmoc linker
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-(Peg)2-Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.