Description

tert-Butyl 2,4-Dichloro-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the dihydropyridopyrimidine class. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies. It is essential for research and development organizations, contract manufacturing organizations (CMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of kinase inhibitor drugs targeting various cancers and inflammatory diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for novel drug candidates within the pyridopyrimidine scaffold.
• Process Development & Scale-Up: Serves as a critical raw material for process chemistry teams during route scouting, optimization, and commercial-scale API manufacturing.
• Contract Synthesis: Supplied to custom synthesis and fine chemical manufacturers for producing bespoke compounds and advanced fragments for drug discovery pipelines.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in API production.

Basic Information

Product Name	tert-Butyl 2,4-Dichloro-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate
CAS No.	916420-27-4
Molecular Formula	C₁₂H₁₄Cl₂N₄O₂
Molecular Weight	317.17 g/mol
Synonyms	7-tert-Butoxycarbonyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; tert-Butyl 2,4-dichloro-7,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxylate; 2,4-Dichloro-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; BOC-2,4-Dichloro-DHPP; 916420-27-4; tert-Butyl 2,4-dichloro-5,6-dihydro-8H-pyrido[3,4-d]pyrimidine-7-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloro-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity (typically ≥97% by HPLC), related substances, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.