Description

3',4',5'-Trifluorobiphenyl-2-Amine is a high-purity fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and functional agrochemicals where the introduction of a trifluoromethyl-substituted biphenyl scaffold is required.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that benefit from fluorinated aromatic systems for enhanced bioactivity and stability.
• Material Science: Serves as a precursor for organic electronic materials, including charge-transport materials and liquid crystals for display technologies.
• Chemical Research: Employed in academic and industrial R&D for cross-coupling reactions (e.g., Buchwald-Hartwig amination) to create complex, functionalized biphenyl derivatives.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments with unique optical properties.

Basic Information

Product Name	3',4',5'-Trifluorobiphenyl-2-Amine
CAS No.	915416-45-4
Molecular Formula	C12H8F3N
Molecular Weight	223.20 g/mol
Synonyms	[2-Amino-3',4',5'-trifluorobiphenyl]; 2-Amino-3',4',5'-trifluoro-1,1'-biphenyl; 3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine; 2-Amino-3',4',5'-trifluorodiphenyl; Biphenyl-2-amine, 3',4',5'-trifluoro-; (3',4',5'-Trifluorobiphenyl-2-yl)amine
EINECS	Contact for details

Quality Control

Our 3',4',5'-Trifluorobiphenyl-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.