Description

8-Chloro-Quinazoline-2,4-Diamine is a high-purity, halogenated quinazoline diamine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role as a versatile intermediate in the development of pharmacologically active molecules, particularly kinase inhibitors and other targeted therapeutics. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to create novel compounds with specific biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based kinase inhibitors for oncology and other therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic structure for bioactivity.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study enzyme function and signal transduction pathways.
• Material Science: Potential monomer or additive in the synthesis of specialized polymers and advanced organic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploratory synthetic chemistry projects.

Basic Information

Product Name	8-Chloro-Quinazoline-2,4-Diamine
CAS No.	915402-33-4
Molecular Formula	C8H7ClN4
Molecular Weight	194.62 g/mol
Synonyms	2,4-Diamino-8-chloroquinazoline; 8-Chloro-2,4-quinazolinediamine; 8-Chloroquinazoline-2,4-diyldiamine; Quinazoline-2,4-diamine, 8-chloro-; 915402-33-4
EINECS	Contact for details

Quality Control

Our 8-Chloro-Quinazoline-2,4-Diamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GLP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.