Description

2-Methyl-4-(Trifluoromethylsulfonyl)Benzenamine is a specialized aromatic amine derivative featuring a trifluoromethylsulfonyl substituent, a key structural motif valued for its electron-withdrawing properties and metabolic stability. This compound is primarily utilized as a crucial advanced pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to introduce fluorinated sulfonamide groups into target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethanesulfonamide group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, sulfonylation processes, and as a directing or protecting group in complex multi-step synthetic routes.
• Research & Development: Critical for medicinal chemistry and process chemistry research in academic institutions and corporate R&D laboratories.
• Dye and Pigment Intermediate: Potential use in the synthesis of specialized colorants and functional dyes.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethylsulfonyl)Benzenamine
CAS No.	914776-04-8
Molecular Formula	C8H8F3NO2S
Molecular Weight	239.21 g/mol
Synonyms	4-Amino-3-methylbenzenesulfonyl fluoride, 1,1,1-trifluoro-; 2-Methyl-4-((trifluoromethyl)sulfonyl)aniline; 4-Amino-α,α,α-trifluoro-3-methylbenzenemethanesulfonate; 3-Methyl-4-aminophenyl trifluoromethyl sulfone; 4-(Trifluoromethylsulfonyl)-2-methylaniline; 2-Methyl-4-(trifluoromethanesulfonyl)aniline; 4-Amino-3-methyl-α,α,α-trifluorobenzenemethanesulfonate
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-4-(Trifluoromethylsulfonyl)Benzenamine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability, consistency, and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.