Description

4-{[4-(Trifluoromethyl)Pyrimidin-2-Yl]Oxy}Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine-benzoic acid hybrid structure. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing new drug candidates and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and synthesis of new drug molecules, especially for oncology, antiviral, and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in developing novel herbicides and fungicides, leveraging the biological activity of the trifluoromethylpyrimidine moiety.
• Ligand & Catalyst Development: Acts as a functionalized building block for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic electronic materials and liquid crystals due to its rigid, aromatic structure.
• Chemical Biology Probes: Utilized in designing molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) serving clients in life sciences.

Basic Information

Product Name	4-{[4-(Trifluoromethyl)Pyrimidin-2-Yl]Oxy}Benzoic Acid
CAS No.	914636-59-2
Molecular Formula	C12H7F3N2O3
Molecular Weight	284.19 g/mol
Synonyms	4-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)benzoic acid; 2-(4-Carboxyphenoxy)-4-(trifluoromethyl)pyrimidine; Benzoic acid, 4-[[4-(trifluoromethyl)-2-pyrimidinyl]oxy]-; 4-({[4-(Trifluoromethyl)pyrimidin-2-yl]}oxy)benzoic acid; 914636-59-2; 4-[[4-(Trifluoromethyl)pyrimidin-2-yl]oxy]benzoic acid
EINECS	Contact for details

Quality Control

Our 4-{[4-(Trifluoromethyl)Pyrimidin-2-Yl]Oxy}Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.