Description

Fmoc-α-Me-Ser(Tbu)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters because it enables the precise incorporation of α-methylserine, a non-proteinogenic amino acid, into peptide chains, allowing researchers to engineer peptides with enhanced stability and specific biological properties. It is critically needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the Fmoc-strategy synthesis of complex peptides.
• Pharmaceutical Research: For the development of peptide drugs with improved metabolic stability by incorporating the α-methylserine residue.
• Bioconjugation & Probe Development: Used to create modified peptides for labeling, imaging, or targeted drug delivery systems.
• Structure-Activity Relationship (SAR) Studies: Essential for exploring the impact of side-chain methylation on peptide bioactivity and conformation.
• Combinatorial Chemistry Libraries: Serves as a valuable component in generating diverse peptide libraries for high-throughput screening.
• Academic & Institutional Research: A fundamental reagent for studies in medicinal chemistry, chemical biology, and protein engineering.

Basic Information

Product Name	Fmoc-α-Me-Ser(Tbu)-Oh
CAS No.	914399-98-7
Molecular Formula	C24H29NO6
Molecular Weight	427.49 g/mol
Synonyms	Fmoc-α-methylserine(t-butyl)-OH; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-α-methyl-L-serine; Fmoc-α-Me-Ser(OtBu)-OH; Fmoc-A-Me-Ser(Tbu)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-[(2-methylpropan-2-yl)oxy]propanoic acid; N-α-Fmoc-O-tert-butyl-α-methyl-L-serine; Fmoc-Ser(Me, tBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-Ser(Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.