Description

1-(6-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid methyl ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine-pyrimidine hybrid structure. This compound matters for its critical role as a versatile building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors and other targeted therapeutics. Pharmaceutical R&D and fine chemical manufacturers need it to develop new drug candidates with enhanced potency and selectivity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drugs.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for constructing potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and cellular signaling.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects at CROs and CDMOs.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents.

Basic Information

Product Name	1-(6-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid methyl ester
CAS No.	914347-88-9
Molecular Formula	C11H14ClN3O2
Molecular Weight	255.70 g/mol
Synonyms	Methyl 1-(6-chloropyrimidin-4-yl)piperidine-4-carboxylate; 1-(6-Chloro-4-pyrimidinyl)-4-piperidinecarboxylic Acid Methyl Ester; 4-Piperidinecarboxylic acid, 1-(6-chloro-4-pyrimidinyl)-, methyl ester; Methyl 1-(6-chloro-4-pyrimidinyl)piperidine-4-carboxylate; 914347-88-9; 1-(6-Chloro-pyrimidin-4-yl)-piperidine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-(6-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid methyl ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.