Description

3-(5-Bromopyrimidin-2-Yloxy)Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a bromopyrimidine core linked to a protected piperidine moiety. This compound is critical for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the production of targeted therapeutics.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of kinase inhibitors and other small-molecule drugs.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and lead optimization campaigns.
• Protease Inhibitor Research: The structural motif is valuable in creating compounds targeting specific protease enzymes.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production.
• Academic Research: Used in university and institutional labs for exploratory organic synthesis and methodology development.

Basic Information

Product Name	3-(5-Bromopyrimidin-2-Yloxy)Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	914347-76-5
Molecular Formula	C14H20BrN3O3
Molecular Weight	358.23 g/mol
Synonyms	1-Boc-3-(5-bromopyrimidin-2-yloxy)piperidine; tert-Butyl 3-((5-bromopyrimidin-2-yl)oxy)piperidine-1-carboxylate; 3-(5-Bromo-2-pyrimidinyloxy)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl 3-[(5-bromopyrimidin-2-yl)oxy]-1-piperidinecarboxylate; 3-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-3-(5-bromopyrimidin-2-yloxy)piperidine; Boc-3-(5-Br-Pyrimidin-2-yloxy)piperidine
EINECS	Contact for details

Quality Control

Our 3-(5-Bromopyrimidin-2-Yloxy)Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development through to commercial scale with cGMP-compliant production options available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.