Description

Methyl 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents. It is primarily sought after by R&D laboratories and pharmaceutical manufacturers engaged in the development of small-molecule drugs, particularly within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Synthesis: Serves as a versatile scaffold for constructing complex heterocyclic compounds in organic synthesis.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for developing new synthetic methodologies and exploring novel chemical spaces.

Basic Information

Product Name	Methyl 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylate
CAS No.	914347-01-6
Molecular Formula	C11H14BrN3O2
Molecular Weight	300.15 g/mol
Synonyms	Methyl 1-(5-bromopyrimidin-2-yl)-4-piperidinecarboxylate; 4-Piperidinecarboxylic acid, 1-(5-bromo-2-pyrimidinyl)-, methyl ester; 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylic acid methyl ester; Methyl 1-(5-bromo-2-pyrimidinyl)piperidine-4-carboxylate; 914347-01-6; Methyl 1-(5-bromo-pyrimidin-2-yl)-piperidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.