Description

2-(5-Chloro-2-Fluorophenyl)Pteridin-4-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated pteridine structure. This compound is of significant value for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Oncology Research: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies due to the pteridine moiety.
• Chemical Biology Probes: Used in academic and industrial research to create molecular probes for studying enzyme function and cellular signaling pathways.
• Process Development & Scale-up: Employed in process chemistry for route scouting, optimization, and pilot-scale production of candidate drug molecules.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	2-(5-Chloro-2-Fluorophenyl)Pteridin-4-Ol
CAS No.	914289-59-1
Molecular Formula	C₁₂H₆ClFN₄O
Molecular Weight	276.65 g/mol
Synonyms	2-(5-Chloro-2-fluorophenyl)-4-pteridinol; 4-Pteridinol, 2-(5-chloro-2-fluorophenyl)-; 2-(5-Chloro-2-fluorophenyl)pyrido[2,3-d]pyrimidin-4-ol; 914289-59-1; 2-(5-Chloro-2-fluorophenyl)-4-hydroxypteridine
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Chloro-2-Fluorophenyl)Pteridin-4-Ol is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.