Description

3-Chloro-4-Fluoro-5-(Trifluoromethyl)Aniline is a high-purity, multi-functional aromatic amine building block of significant commercial and research interest. Its unique molecular structure, featuring chloro, fluoro, and trifluoromethyl substituents, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and production specialists in the agrochemical, pharmaceutical, and specialty chemical industries seeking to introduce specific steric and electronic properties into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a core building block for advanced herbicides, fungicides, and insecticides, where the halogenated aniline structure contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Acts as a monomer or curing agent to impart specific chemical resistance, thermal stability, or surface properties to advanced polymers.
• Dye & Pigment Intermediate: Employed in the production of specialized, high-performance colorants and pigments.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	3-Chloro-4-Fluoro-5-(Trifluoromethyl)Aniline
CAS No.	914225-61-9
Molecular Formula	C7H4ClF4N
Molecular Weight	213.56 g/mol
Synonyms	3-Chloro-4-fluoro-5-(trifluoromethyl)benzenamine; 5-Amino-2-chloro-1-fluoro-3-(trifluoromethyl)benzene; 2-Chloro-1-fluoro-3-(trifluoromethyl)-5-aminobenzene; Benzenamine, 3-chloro-4-fluoro-5-(trifluoromethyl)-; 3-Chloro-4-fluoro-5-trifluoromethylaniline; 3-Chloro-4-fluoro-alpha,alpha,α-trifluoro-m-toluidine
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoro-5-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.