Description

4-Isopropyl-2-Trifluoromethyl Pyrimidine-5-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its pyrimidine core substituted with a carboxylic acid group, an isopropyl moiety, and a trifluoromethyl group. This unique structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine and trifluoromethyl groups.
• Material Science Research: Serves as a precursor for designing specialty chemicals, ligands for catalysis, and functional materials.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.
• Academic & Industrial R&D: Utilized in medicinal chemistry and process chemistry research for structure-activity relationship (SAR) studies and route scouting.

Basic Information

Product Name	4-Isopropyl-2-Trifluoromethyl Pyrimidine-5-Carboxylic Acid
CAS No.	914201-22-2
Molecular Formula	C9H9F3N2O2
Molecular Weight	234.18 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 4-(1-methylethyl)-2-(trifluoromethyl)-; 4-(Propan-2-yl)-2-(trifluoromethyl)pyrimidine-5-carboxylic acid; 2-Trifluoromethyl-4-isopropyl-pyrimidine-5-carboxylic acid; 4-Isopropyl-2-trifluoromethyl-5-pyrimidinecarboxylic acid; 4-Isopropyl-2-(trifluoromethyl)pyrimidine-5-carboxylic acid; CAS 914201-22-2
EINECS	Contact for details

Quality Control

Our 4-Isopropyl-2-Trifluoromethyl Pyrimidine-5-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay and impurity profiles. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.