Description

4-Cyclopropyl-2-Pentafluoro Ethyl-Pyrimidine-5-Carboxylic Acid is a high-value, fluorinated pyrimidine carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the unique combination of the cyclopropyl and pentafluoroethyl groups, which are instrumental in modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients requiring enhanced metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in developing antiviral, anticancer, and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated moiety improves compound activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where the fluorine atoms contribute to thermal stability and unique optical properties.
• Chemical Biology & Probe Development: Utilized in designing molecular probes and tags for studying biological processes due to the distinctive signature of the fluorine atoms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4-Cyclopropyl-2-Pentafluoro Ethyl-Pyrimidine-5-Carboxylic Acid
CAS No.	914201-14-2
Molecular Formula	C11H9F5N2O2
Molecular Weight	296.20 g/mol
Synonyms	4-Cyclopropyl-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid; 2-(Pentafluoroethyl)-4-cyclopropylpyrimidine-5-carboxylic Acid; 5-Pyrimidinecarboxylic acid, 4-cyclopropyl-2-(pentafluoroethyl)-; 914201-14-2; 4-Cyclopropyl-2-(1,1,2,2,2-pentafluoroethyl)pyrimidine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Cyclopropyl-2-Pentafluoro Ethyl-Pyrimidine-5-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our facilities and processes are designed to support development through to commercial scale, meeting the rigorous standards required for pharmaceutical and advanced chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.