Description

Fmoc-(2R,4S)-Pro(4-F)-Oh is a high-purity, fluorinated proline derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This chiral building block is essential for the solid-phase synthesis of complex peptides, enabling the precise introduction of structural constraints and enhanced stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical R&D: Used in the discovery and development of peptide-based drugs targeting GPCRs, enzymes, and protein-protein interactions.
• Peptidomimetic Design: Incorporation of the fluorinated proline ring influences backbone conformation and metabolic stability, key for drug optimization.
• Chemical Biology: Synthesis of labeled or modified peptides for studying biological mechanisms and protein functions.
• Bioconjugation: Serves as a specialized component for creating peptide-drug conjugates or peptide-based materials.
• Academic Research: Fundamental studies in peptide chemistry, stereochemistry, and fluorine chemistry.

Basic Information

Product Name	Fmoc-(2R,4S)-Pro(4-F)-Oh
CAS No.	913820-87-8
Molecular Formula	C₂₁H₂₀FNO₅
Molecular Weight	385.39 g/mol
Synonyms	Fmoc-(2R,4S)-4-fluoroproline; (2R,4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic Acid; Fmoc-(2R,4S)-4-Fluoro-Pro-OH; N-α-Fmoc-trans-4-fluoro-L-proline; Fmoc-4-Fluoro-L-proline (trans); N-(9-Fluorenylmethoxycarbonyl)-trans-4-fluoro-L-proline; Fmoc-4-F-Pro-OH; Fmoc-4-F-Proline
EINECS	Contact for details

Quality Control

Every batch of Fmoc-(2R,4S)-Pro(4-F)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥98% by HPLC), chiral purity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.