Description

n-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(Phenylmethoxy)-4-Quinazolinamine is a high-purity, advanced pharmaceutical intermediate. This compound is a key building block in the synthesis of targeted therapeutic agents, offering critical structural features for drug discovery and development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted oncology drugs and kinase inhibitors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in multi-step synthetic routes for final active compounds.
• Biochemical Research: Employed as a reference standard or probe in biochemical assays to study enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	n-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(Phenylmethoxy)-4-Quinazolinamine
CAS No.	913819-12-2
Molecular Formula	C22H17ClFN3O2
Molecular Weight	409.84 g/mol
Synonyms	6-(Benzyloxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine; 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(phenylmethoxy)-; BIBX 1382; BIBX1382; BIBX-1382; EGFR Inhibitor BIBX 1382; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[(phenylmethyl)oxy]-4-quinazolinamine
EINECS	Contact for details

Quality Control

Our n-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(Phenylmethoxy)-4-Quinazolinamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.