Description

Fmoc-N-Me-Arg(Pbf)-OH is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of N-methylated arginine residues, which are key to enhancing peptide stability, bioavailability, and biological activity. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and CROs/CMOs engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of complex peptides.
• Therapeutic Peptide Development: For incorporating N-methyl-arginine motifs to improve metabolic stability and membrane permeability of peptide drug candidates.
• Peptidomimetic Research: Used in the design and synthesis of modified peptides that mimic protein structures for drug discovery.
• Biochemical Probe Synthesis: Manufacturing labeled or modified peptides used as tools in molecular biology and proteomics research.
• GPCR Ligand and Enzyme Inhibitor Development: Critical for creating peptides that target specific receptors or enzymatic pathways.
• Custom Peptide Services: A fundamental reagent for CROs and CMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-N-Me-Arg(Pbf)-OH
CAS No.	913733-27-4
Molecular Formula	C33H46N4O7S
Molecular Weight	642.81 g/mol
Synonyms	Fmoc-NG-methyl-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)arginine; Fmoc-N-methylarginine(Pbf)-OH; N-α-Fmoc-N-ω-(Pbf)-N'-methyl-L-arginine; Fmoc-NG-Me-Arg(Pbf)-OH; Fmoc-N-methyl-NG-(Pbf)-L-arginine; (2S)-5-[[(2,2,4,6,7-Pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]-(methyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; N-α-(9-Fluorenylmethyloxycarbonyl)-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-N'-methyl-L-arginine
EINECS	Contact for details

Quality Control

Our Fmoc-N-Me-Arg(Pbf)-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) with full chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.