Description

4-[4-(Trifluoromethoxy)Phenyl]Pyrimidine-2-Carboxylic Acid is a high-value, multifunctional heterocyclic building block essential for advanced organic synthesis. This compound is critical for research and development in the pharmaceutical and agrochemical sectors, where its unique trifluoromethoxy-substituted aromatic pyrimidine core enables the creation of novel bioactive molecules. It is primarily sought after by R&D chemists and process development scientists working on new active ingredients, particularly for applications requiring specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethoxy group.
• Material Science Precursor: Serves as a building block for functionalized organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-[4-(Trifluoromethoxy)Phenyl]Pyrimidine-2-Carboxylic Acid
CAS No.	912850-80-7
Molecular Formula	C12H7F3N2O3
Molecular Weight	284.19 g/mol
Synonyms	2-Pyrimidinecarboxylic acid, 4-[4-(trifluoromethoxy)phenyl]-; 4-(4-(Trifluoromethoxy)phenyl)pyrimidine-2-carboxylic acid; 4-(4-Trifluoromethoxyphenyl)-2-pyrimidinecarboxylic acid; 4-(4-(Trifluoromethoxy)phenyl)pyrimidine-2-carboxylate; 912850-80-7; 4-(4-Trifluoromethoxyphenyl)pyrimidine-2-carboxylic acid; 4-[4-(Trifluoromethoxy)phenyl]-2-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-[4-(Trifluoromethoxy)Phenyl]Pyrimidine-2-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to reliable supply and traceable quality supports your regulatory and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. Keep away from incompatible materials such as strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.