Description

tert-Butyl 2-Fluoro-4-Hydroxyphenylcarbamate is a high-purity, protected intermediate of significant importance in modern synthetic chemistry. Its core value lies in providing a versatile and stable building block for the construction of complex molecules, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of novel drug candidates, especially those containing fluorinated aromatic systems.
• API Synthesis: Used in the development and scale-up of Active Pharmaceutical Ingredients (APIs) where the tert-butyloxycarbonyl (Boc) protecting group and fluorine atom are required structural motifs.
• Agrochemical Research: Serves as a building block for creating new fluorinated herbicides, pesticides, and fungicides, leveraging the metabolic stability often imparted by fluorine.
• Peptide & Organic Synthesis: Functions as a Boc-protected aniline derivative, useful in medicinal chemistry for constructing complex organic scaffolds and peptide mimetics.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for studying biological systems and mechanisms.
• Material Science Precursor: Potential use as a monomer or intermediate in the synthesis of specialized polymers and advanced organic materials.

Basic Information

Product Name	tert-Butyl 2-Fluoro-4-Hydroxyphenylcarbamate
CAS No.	911297-02-4
Molecular Formula	C11H14FNO3
Molecular Weight	227.23 g/mol
Synonyms	2-Fluoro-4-hydroxycarbanilic acid tert-butyl ester; tert-Butyl N-(2-fluoro-4-hydroxyphenyl)carbamate; Boc-2-Fluoro-4-hydroxyaniline; N-Boc-2-Fluoro-4-aminophenol; N-(tert-Butoxycarbonyl)-2-fluoro-4-aminophenol; 4-((tert-Butoxycarbonyl)amino)-3-fluorophenol; 2-Fluoro-4-((((2-methylpropan-2-yl)oxy)carbonyl)amino)phenol
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Fluoro-4-Hydroxyphenylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.